Design, Synthesis, Characterization and Biological Evaluation of Some Novel 1, 5 Disubstituted Tetrazole as Potential Anti-inflammatory Agents
نویسندگان
چکیده
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro anti-inflammatory activity of various 1-[5-(substituted phenyl)-1-phenyl-4,5dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole (IV a-h).The anti-inflammatory activity of title compounds were examined by denaturation of proteins method. All the compounds exhibited weak to potent anti-inflammatory activity. Some derivatives bearing a methoxy group exhibited very good anti-inflammatory activity.
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